Description

1-Fluoro-3-Hydroxy-2-Propanone is a versatile fluorinated building block and key synthetic intermediate. Its unique structure, featuring both a fluorine atom and a reactive ketone/hydroxyl functionality, makes it valuable for introducing fluorine into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel fluorinated compounds with enhanced biological activity, metabolic stability, or specific physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to create advanced fluorinated herbicides, fungicides, and pesticides, where the fluorine atom can improve efficacy and environmental profile.
• Fluorinated Material Science: Serves as a monomer or modifier in the production of specialty polymers, coatings, and liquid crystals with tailored surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and condensation reactions to construct complex fluorinated heterocycles and fine chemicals.
• Biochemical Research: Used as a probe or tracer in metabolic studies and for developing enzyme inhibitors, leveraging fluorine's NMR-active properties.
• Radiopharmaceutical Precursor: Potential use as a synthon for the preparation of 18F-labeled compounds used in Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	1-Fluoro-3-Hydroxy-2-Propanone
CAS No.	62522-70-7
Molecular Formula	C3H5FO2
Molecular Weight	92.07 g/mol
Synonyms	3-Fluoro-2-hydroxy-1-propanone; 3-Fluoro-2-oxopropyl alcohol; 1-Fluoro-3-hydroxyacetone; 2-Hydroxy-3-fluoropropanone; 3-Fluoro-2-hydroxypropanone; 2-Oxo-3-fluoropropyl alcohol; Fluorohydroxyacetone; 3-Fluoro-2-oxopropanol
EINECS	Contact for details

Quality Control

Our 1-Fluoro-3-Hydroxy-2-Propanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.