Description

4'-Chloro-5-Fluoro-2-Hydroxybenzophenone is a high-purity, halogenated benzophenone derivative serving as a critical advanced pharmaceutical intermediate. This compound matters because it provides the essential molecular scaffold for synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise structural modification. Pharmaceutical R&D laboratories and fine chemical manufacturers need this intermediate for developing next-generation drugs, leveraging its unique substitution pattern to modulate biological activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for various therapeutic classes.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the chloro-fluoro-hydroxy substitution pattern can influence bioactivity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers with specific optical or thermal properties.
• UV Absorber Synthesis: Intermediate for manufacturing advanced, high-performance ultraviolet light absorbers used in coatings and plastics.
• Liquid Crystal & OLED Materials: Aromatic core component in the research and production of organic electronic materials.
• Organic Synthesis & Catalysis Research: Valuable substrate in academic and industrial research for studying new organic reactions and catalytic processes.

Basic Information

Product Name	4'-Chloro-5-Fluoro-2-Hydroxybenzophenone
CAS No.	62433-26-5
Molecular Formula	C13H8ClFO2
Molecular Weight	250.65 g/mol
Synonyms	5-Fluoro-2-hydroxy-4'-chlorobenzophenone; (5-Fluoro-2-hydroxyphenyl)(4-chlorophenyl)methanone; 2-Hydroxy-4'-chloro-5-fluorobenzophenone; 4'-Chloro-5-fluorosalicylophenone; Benzophenone, 4'-chloro-5-fluoro-2-hydroxy-; 2-Benzoyl-4-chlorophenyl 5-fluorophenyl ether (tautomeric form); CFHB; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our 4'-Chloro-5-Fluoro-2-Hydroxybenzophenone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of pharmaceutical R&D and fine chemical synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.