Description

3,5-Difluorobiphenyl is a high-purity fluorinated biphenyl derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique substitution pattern, which makes it an essential building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluorobiphenyl core contributes to improved bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a foundational unit in the production of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, enhancing charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific characteristics such as increased chemical resistance, lower dielectric constant, or enhanced thermal performance.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille) to introduce the difluorobiphenyl moiety into more complex molecular architectures for research and scale-up.
• Ligand & Catalyst Development: Utilized in the design and synthesis of novel ligands for catalysis, leveraging the fluorine atoms to fine-tune electronic properties and metal coordination.

Basic Information

Product Name	3,5-Difluorobiphenyl
CAS No.	62351-48-8
Molecular Formula	C12H8F2
Molecular Weight	190.19 g/mol
Synonyms	1,3-Difluoro-5-phenylbenzene; Biphenyl, 3,5-difluoro-; 3,5-Difluoro-1,1'-biphenyl; [1,1'-Biphenyl]-3,5-difluoro; 3,5-Difluorodiphenyl
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobiphenyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.