Description

n-Butanol, [1-14C] is a carbon-14 labeled isotopologue of n-butanol, a primary alcohol with the radioactive label specifically positioned at the first carbon atom. This compound is essential for precise metabolic and pharmacokinetic studies, enabling researchers to trace the fate of butanol and its derivatives in complex biological and chemical systems. It is a critical tool for scientists in pharmaceutical research, agrochemical development, and environmental science who require high-specific-activity tracers for autoradiography, LC-MS, and other advanced analytical techniques.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled precursor to study the absorption, distribution, metabolism, and excretion (ADME) of butanol and related compounds in vivo and in vitro.
• Pharmaceutical Research: Critical for drug metabolism and pharmacokinetics (DMPK) studies to identify metabolites and understand drug clearance mechanisms.
• Chemical Reaction Mechanism Studies: Employed to elucidate reaction pathways and intermediates in organic synthesis and catalysis where butanol is a solvent, reagent, or product.
• Environmental Fate Studies: Tracks the degradation, transformation, and environmental persistence of butanol and its derivatives in soil and water systems.
• Agrochemical Development: Utilized in research on herbicides, pesticides, or plant growth regulators that incorporate or metabolize butanol structures.
• Biochemical Research: Serves as a labeled substrate for enzymatic studies involving alcohol dehydrogenases and other enzymes that act on short-chain alcohols.

Basic Information

Product Name	n-Butanol, [1-14C]
CAS No.	61990-73-6
Molecular Formula	C4H914COH
Molecular Weight	~75.1 g/mol (varies with specific activity)
Synonyms	1-Butanol-1-14C; Butan-1-ol-1-14C; n-Butyl alcohol-1-14C; [1-14C]Butan-1-ol; 1-14C-Butanol; Radioactive butanol; Carbon-14 labeled n-butanol; Butanol-1-C14
EINECS	Contact for details

Quality Control

Every batch of n-Butanol, [1-14C] is manufactured and analyzed under strict quality systems to ensure radiochemical purity, chemical purity, and specific activity meet the exacting standards required for research. Comprehensive Certificates of Analysis (COA) are provided, detailing parameters such as radionuclidic purity, radiochemical concentration, and analytical chromatography results. Our commitment to cGMP-compliant practices ensures traceability and reliability for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at the recommended temperature (typically 2-8°C or as specified on the label) in a designated, well-ventilated area for radioactive materials. Due to its highly volatile nature, ensure containers are securely sealed to prevent evaporation and potential contamination. Follow all local and international regulations for the storage and handling of radioactive substances.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Specific Activity	Customized (mCi/mmol)
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (GC)	≥ 98%
Radionuclidic Purity	≥ 99%
Concentration	Customized (mCi/mL in suitable solvent)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.