Description

2-Methyl-2-Trimethylsilyl-3-Hexyne is a specialized organosilicon building block featuring both a silyl-protected alkyne and a tertiary carbon center. This unique molecular structure makes it a valuable intermediate in advanced organic synthesis, particularly for constructing complex frameworks. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex drug candidates, leveraging the silyl group for protection and the alkyne for coupling reactions.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where its structural motifs can contribute to unique biological activity.
• Material Science: Acts as a precursor for silicon-containing polymers or advanced organic materials with tailored properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Sonogashira) and nucleophilic additions to construct carbon-carbon bonds in complex molecule assembly.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new synthetic pathways in laboratory settings.

Basic Information

Product Name	2-Methyl-2-Trimethylsilyl-3-Hexyne
CAS No.	61227-99-4
Molecular Formula	C₁₀H₂₀Si
Molecular Weight	168.35 g/mol
Synonyms	2-Methyl-2-(trimethylsilyl)-3-hexyne; 3-Hexyne, 2-methyl-2-(trimethylsilyl)-; Trimethyl(1,1-dimethylbut-1-yn-1-yl)silane; (1,1-Dimethylbut-1-yn-1-yl)trimethylsilane; TMS-protected tertiary alkyne
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-Trimethylsilyl-3-Hexyne is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and FTIR, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee it meets the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.