Description

Prostratin, Pkc Activator CAS NO 60857-08-1 is a bioactive diterpene ester known for its potent and specific activation of protein kinase C (PKC) isoforms. This compound is a critical research tool for studying PKC-mediated signal transduction pathways, which are involved in numerous cellular processes including proliferation, differentiation, and apoptosis. It is primarily utilized by researchers and developers in the fields of pharmacology, oncology, and molecular biology for drug discovery and mechanistic studies.

Application

• Biomedical Research: A key pharmacological tool for investigating the role of PKC signaling in cancer, immune response, and neurological disorders.
• Drug Discovery & Development: Used in high-throughput screening assays to identify and validate novel therapeutic agents targeting PKC pathways.
• Cell Biology Studies: Employed to induce cellular differentiation, study apoptosis, and explore mechanisms of T-cell activation and latency reversal in virology.
• Biochemical Assays: Serves as a positive control and standard in enzymatic assays to measure PKC activity and inhibition.
• Academic Research: Fundamental reagent for universities and research institutes exploring signal transduction and cell regulation.

Basic Information

Product Name	Prostratin, Pkc Activator CAS NO 60857-08-1
CAS No.	60857-08-1
Molecular Formula	C22H30O6
Molecular Weight	390.47 g/mol
Synonyms	Prostratin; 12-Deoxyphorbol 13-acetate; NSC 614471; 13-O-Acetyl-12-deoxyphorbol; 12-Deoxyphorbol-13-acetate; PKC Activator Prostratin; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b,9-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl acetate
EINECS	Contact for details

Quality Control

Our Prostratin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.