Description

2-Chloro-2',5'-Difluoroacetophenone is a specialized fluorinated and chlorinated aromatic ketone building block. This compound is valued for its unique halogenated structure, which imparts specific reactivity and electronic properties crucial for advanced chemical synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those requiring difluorinated and chlorinated aromatic motifs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the halogen atoms can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the synthesis of specialty polymers, liquid crystals, or organic electronic materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic compounds like imidazoles or pyrazoles.
• Chemical Reference Standard: Used in analytical laboratories for method development and quality control testing of related substances.

Basic Information

Product Name	2-Chloro-2',5'-Difluoroacetophenone
CAS No.	60468-36-2
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	1-(2,5-Difluorophenyl)-2-chloroethanone; 2-Chloro-1-(2,5-difluorophenyl)ethanone; 2',5'-Difluoro-2-chloroacetophenone; α-Chloro-2,5-difluoroacetophenone; 2-Chloro-2,5-difluoroacetophenone; (2,5-Difluorophenyl)(chloro)methanone
EINECS	Contact for details

Quality Control

Our 2-Chloro-2',5'-Difluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.