Description

Norbenzoylecgonine Hydrochloride is a high-purity chemical reference standard and synthetic intermediate of significant importance in analytical and pharmaceutical research. Its primary value lies in its role as a key metabolite and precursor, enabling precise analytical calibration and controlled synthesis pathways. This compound is essential for forensic laboratories, toxicology research, and pharmaceutical development teams requiring reliable reference materials for method validation and quality control.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of cocaine metabolites in forensic and clinical toxicology.
• Forensic Science: Critical for calibrating equipment (GC-MS, LC-MS/MS) in drug testing laboratories to ensure accurate legal and workplace testing results.
• Pharmaceutical Research: Serves as a key intermediate or metabolite standard in the development and testing of pharmacological agents and addiction treatments.
• Clinical Toxicology: Used to validate analytical methods for detecting and monitoring drug exposure in human biological samples (urine, blood, hair).
• Method Development & Validation: Essential for establishing and verifying the accuracy, precision, and specificity of new analytical protocols in regulated laboratories.
• Quality Control (QC) Testing: Employed by manufacturers of diagnostic kits and reagents to ensure batch-to-batch consistency and performance.

Basic Information

Product Name	Norbenzoylecgonine Hydrochloride
CAS No.	60426-41-7
Molecular Formula	C15H19NO4 • HCl
Molecular Weight	313.78 g/mol (free base: 277.32 g/mol)
Synonyms	Norbenzoylecgonine HCl; Norbenzoylecgonine Hydrochloride; 3-Carboxybenzoylecgonine; Benzoylecgonine-3-carboxylic acid hydrochloride; Ecgonine, 3-benzoyl-, hydrochloride (8CI); Nor-Benzoylecgonine Hydrochloride; Cocaethylene metabolite analog; 2-Carbomethoxy-3-benzoyloxy-8-azabicyclo[3.2.1]octane-4-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our Norbenzoylecgonine Hydrochloride is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and impurity profiles. We adhere to relevant guidelines for reference standards, and specifications can be tailored to meet specific pharmacopeial or internal method requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.