Description

2-Cyclobuten-1-One, 4,4-Difluoro-2,3-Dimethoxy- is a highly functionalized cyclobutenone derivative, serving as a versatile and valuable building block in advanced organic synthesis. Its unique strained-ring structure, combined with fluorine and methoxy substituents, makes it a critical precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or optical properties.
• Organic Synthesis Building Block: Employed in [4+2] cycloaddition reactions and other ring-opening or functionalization transformations to create complex, chiral molecules.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution on reactivity and stereochemistry in small, strained ring systems.

Basic Information

Product Name	2-Cyclobuten-1-One, 4,4-Difluoro-2,3-Dimethoxy-
CAS No.	60376-35-4
Molecular Formula	C6H6F2O3
Molecular Weight	164.11 g/mol
Synonyms	4,4-Difluoro-2,3-dimethoxy-2-cyclobuten-1-one; 4,4-Difluoro-2,3-dimethoxycyclobut-2-en-1-one; 2,3-Dimethoxy-4,4-difluorocyclobut-2-enone; Difluorodimethoxycyclobutenone; 2-Cyclobuten-1-one, 4,4-difluoro-2,3-dimethoxy-; 60376-35-4
EINECS	Contact for details

Quality Control

Our 2-Cyclobuten-1-One, 4,4-Difluoro-2,3-Dimethoxy- is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR (1H, 13C, 19F), and mass spectrometry for full structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.