Description

Lithium Trisiamylborohydride is a highly selective and powerful reducing agent, belonging to the family of sterically hindered borohydrides. Its core value proposition lies in its exceptional ability to perform stereoselective reductions of ketones and aldehydes under mild conditions, offering superior chemoselectivity compared to traditional reagents like lithium aluminum hydride. This makes it an indispensable tool for synthetic organic chemists and process development scientists working in pharmaceutical intermediates, fine chemical synthesis, and advanced material research.

Application

• Stereoselective Synthesis: Key reagent for the enantioselective reduction of prochiral ketones to produce chiral alcohols, crucial for active pharmaceutical ingredient (API) manufacturing.
• Fine Chemical Production: Used in the synthesis of complex organic molecules, fragrances, and agrochemical intermediates where precise control over stereochemistry is required.
• Polymer Chemistry: Acts as a reducing agent and initiator in the development of specialty polymers and advanced materials.
• Academic & R&D Laboratories: A staple reagent for methodological development and exploratory synthesis in organic chemistry research.
• Process Chemistry Optimization: Employed to develop cleaner, more efficient, and scalable synthetic routes in industrial chemical processes.

Basic Information

Product Name	Lithium Trisiamylborohydride
CAS No.	60217-34-7
Molecular Formula	C15H34BLi
Molecular Weight	232.19 g/mol
Synonyms	Lithium Tri(3-methylbutyl)borohydride; L-Selectride® (Common Trade Name); Lithium Tris(3-methylbutyl)borohydride; Lithium Triisoamylborohydride; Trisiamylborohydride Lithium Salt; Borate(1-), tri(3-methylbutyl)hydro-, lithium (1:1); Lithium hydrotris(3-methylbutyl)borate(1-)
EINECS	Contact for details

Quality Control

Our Lithium Trisiamylborohydride is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including assay by titration and impurity profile analysis. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality management system supports compliance with cGMP and ISO standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C. Due to its highly volatile nature, ensure containers are securely sealed and handled in a well-ventilated area or glove box.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	1.0 M in THF or as specified
Assay (Titration)	≥ 95.0%
Identification (IR)	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.