Description

(2R)-2-Chloro-1-phenylpropan-1-one, also known as 1-Propanone, 2-Chloro-1-Phenyl-, (2R)- (9Ci) with CAS number 60027-51-2, is a chiral α-chloroketone of significant interest in advanced organic synthesis. This compound serves as a crucial chiral building block and intermediate for the preparation of enantiomerically pure pharmaceuticals and fine chemicals. It is particularly valuable for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce stereochemical complexity into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system.
• Asymmetric Synthesis: Employed as a chiral electrophile or building block in stereoselective carbon-carbon bond-forming reactions.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a starting material for the synthesis of chiral ligands and organocatalysts.
• Fine Chemical Production: Intermediate for flavors, fragrances, and other high-value specialty chemicals requiring specific stereochemistry.
• Academic & Industrial R&D: Essential reagent for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Item	Detail
Product Name	(2R)-2-Chloro-1-phenylpropan-1-one
CAS No.	60027-51-2
Molecular Formula	C9H9ClO
Molecular Weight	168.62 g/mol
Synonyms	(R)-2-Chloro-1-phenylethanone; (R)-2-Chloroacetophenone; (R)-ω-Chloroacetophenone; (2R)-2-Chloro-1-phenylethanone; (R)-α-Chloroacetophenone; (R)-Phenacyl chloride; 1-Propanone, 2-chloro-1-phenyl-, (2R)-; (R)-(-)-2-Chloroacetophenone
EINECS	Contact for details

Quality Control

Our (2R)-2-Chloro-1-phenylpropan-1-one is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We employ advanced analytical techniques, including chiral HPLC and NMR spectroscopy, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The compound is sensitive to light and moisture; containers should be kept sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.