Description

1,3-Diphenyl-2-Bromo-2-Propene-1-One is a specialized brominated chalcone derivative, serving as a versatile and reactive synthetic intermediate. Its core value lies in its α-bromoketone functionality, which makes it a key building block for constructing complex molecular architectures through nucleophilic substitution and cross-coupling reactions. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science who require high-purity intermediates for precise chemical transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing diaryl ketone or modified chalcone scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Organic Synthesis Building Block: Employed in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to introduce the diphenylpropenone moiety.
• Material Science Research: Acts as a monomer or precursor for the development of organic semiconductors, liquid crystals, and photoresponsive polymers.
• Chemical Biology Probe Development: Utilized in creating molecular probes to study enzyme inhibition and protein-ligand interactions due to its reactive bromine handle.
• Academic & R&D Laboratories: Serves as a standard reagent for methodological studies in synthetic organic chemistry and catalysis.

Basic Information

Product Name	1,3-Diphenyl-2-Bromo-2-Propene-1-One
CAS No.	6935-75-7
Molecular Formula	C15H11BrO
Molecular Weight	287.15 g/mol
Synonyms	2-Bromo-1,3-diphenyl-2-propen-1-one; 2-Bromochalcone; α-Bromochalcone; (E)-2-Bromo-1,3-diphenylprop-2-en-1-one; 1,3-Diphenyl-2-bromo-2-propen-1-one; NSC 403116; Bromochalcone; 2-Bromo-1,3-diphenylprop-2-en-1-one
EINECS	Contact for details

Quality Control

Our 1,3-Diphenyl-2-Bromo-2-Propene-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), melting point, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	88 - 92 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.