Description

(4As,3Ar)-5,6,6Aα,7,9Aβ,9Bα-Hexahydro-1,4A,7α-Trimethyl-3H-Oxireno[8,8A]Azuleno[4,5-B]Furan-8(4Ah)-One is a complex, high-purity sesquiterpene lactone derivative with a unique oxireno-azulene fused ring structure. This compound is valued as a critical advanced pharmaceutical intermediate and a versatile scaffold for synthetic organic chemistry research. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, particularly in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its intricate polycyclic framework.
• Natural Product Synthesis: Acts as a synthetic target or intermediate in the total synthesis of complex sesquiterpenoid natural products.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and enzyme interactions.
• Asymmetric Synthesis: Employed as a substrate or template in catalytic asymmetric reactions to construct stereochemically complex molecules.
• High-Purity Reference Standard: Supplied as an analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(4As,3Ar)-5,6,6Aα,7,9Aβ,9Bα-Hexahydro-1,4A,7α-Trimethyl-3H-Oxireno[8,8A]Azuleno[4,5-B]Furan-8(4Ah)-One
CAS No.	6831-14-7
Molecular Formula	C₁₅H₁₈O₃
Molecular Weight	246.30 g/mol
Synonyms	8-Oxo-1,4a,7a-trimethyl-3a,4,4a,5,6,7,7a,8,9,9a-decahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan; Parthenolide analog; Oxirenoazulenone derivative; Sesquiterpene lactone epoxide; 1,4a,7a-Trimethyl-8-oxo-3a,4,4a,5,6,7,7a,8,9,9a-decahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan
EINECS	Contact for details

Quality Control

Our production of (4As,3Ar)-5,6,6Aα,7,9Aβ,9Bα-Hexahydro-1,4A,7α-Trimethyl-3H-Oxireno[8,8A]Azuleno[4,5-B]Furan-8(4Ah)-One adheres to stringent cGMP guidelines where applicable, ensuring batch-to-batch consistency for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.