Description

1-Naphthyl Trifluoromethyl Ketone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the electron-withdrawing trifluoromethyl group adjacent to the carbonyl, enabling precise molecular construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly those requiring the metabolic stability and lipophilicity of the trifluoromethyl group.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the naphthyl-trifluoromethyl motif can enhance biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Functional Material Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other advanced materials requiring tailored electronic properties.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the behavior of fluorinated aromatic systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring high-purity fluorinated building blocks.

Basic Information

Product Name	1-Naphthyl Trifluoromethyl Ketone
CAS No.	6500-37-4
Molecular Formula	C12H7F3O
Molecular Weight	224.18 g/mol
Synonyms	1-Acetylnaphthalene, 2,2,2-trifluoro-; 2,2,2-Trifluoro-1-(1-naphthyl)ethanone; 1-Naphthalenyl trifluoromethyl ketone; α,α,α-Trifluoro-1-naphthyl methyl ketone; 1-(Trifluoroacetyl)naphthalene; Naphthalen-1-yl(trifluoro)methanone; TFNK
EINECS	Contact for details

Quality Control

Our 1-Naphthyl Trifluoromethyl Ketone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality system is designed to meet the stringent requirements of research and fine chemical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.