Description

Ethyl 2,2-Dichloroacetoacetate is a versatile and highly reactive organic ester, serving as a critical building block in advanced chemical synthesis. Its value lies in the presence of two reactive chlorine atoms and an active methylene group, enabling its use in the construction of complex heterocyclic and pharmaceutical intermediates. This compound is essential for R&D chemists and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various heterocyclic compounds, including pyrazoles and pyrimidines, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, leveraging its reactivity to create novel crop protection molecules.
• Chemical Research & Development: A valuable reagent for constructing complex molecular architectures in academic and industrial R&D settings.
• Dye and Pigment Industry: Employed as an intermediate in the production of certain specialized dyes and organic pigments.
• Complex Ligand Synthesis: Serves as a starting material for the preparation of chelating agents and ligands used in catalysis and metal coordination chemistry.

Basic Information

Product Name	Ethyl 2,2-Dichloroacetoacetate
CAS No.	6134-66-3
Molecular Formula	C6H8Cl2O3
Molecular Weight	199.04 g/mol
Synonyms	2,2-Dichloro-3-oxobutanoic Acid Ethyl Ester; Ethyl 2,2-Dichloro-3-oxobutanoate; Acetoacetic Acid, 2,2-Dichloro-, Ethyl Ester; Ethyl Dichloroacetoacetate; 3-Oxobutanoic Acid, 2,2-Dichloro-, Ethyl Ester; Ethyl α,α-Dichloroacetoacetate; NSC 404058
EINECS	228-106-5

Quality Control

Our Ethyl 2,2-Dichloroacetoacetate is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is typically stable at controlled room temperature for shorter periods. The compound is compatible with strong acid/organic solvent environments but should be handled with appropriate precautions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.455 - 1.465
Density (20°C)	1.30 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.