Description

5,5,5-Trifluoro-4-oxopentanoic acid is a versatile fluorinated keto acid building block, prized for its unique trifluoromethyl group which imparts enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for the synthesis of advanced intermediates in pharmaceutical and agrochemical research, where the introduction of fluorine atoms is a key strategy for optimizing bioactivity. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), particularly protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral auxiliaries and fluorinated ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with specific surface properties.
• Fluorine Chemistry Research: A valuable building block in academic and industrial laboratories for exploring new fluorination methodologies and compound libraries.

Basic Information

Product Name	5,5,5-Trifluoro-4-oxopentanoic Acid
CAS No.	684-76-4
Molecular Formula	C5H5F3O3
Molecular Weight	170.09 g/mol
Synonyms	4,4,4-Trifluoro-3-oxobutanoic Acid; 5,5,5-Trifluoro-4-oxopentanoic Acid; 3-Oxo-4,4,4-trifluorobutanoic Acid; 4,4,4-Trifluoroacetoacetic Acid; 3-Oxo-4,4,4-trifluorobutyric Acid; TFAA; Trifluoroacetoacetic Acid
EINECS	211-688-7

Quality Control

Every batch of 5,5,5-Trifluoro-4-oxopentanoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its nature as a strong acid/organic solvent, it should be kept away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.