Description

Methyl Bromodifluoroacetate is a versatile fluorinated building block and reagent essential for advanced organic synthesis. This compound is valued for its ability to introduce the difluoroacetate moiety, enabling the creation of complex molecules with tailored properties. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated active pharmaceutical ingredients (APIs), where fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides, leveraging fluorine's ability to improve lipophilicity and target binding.
• Material Science: Serves as a precursor for fluorinated polymers, coatings, and liquid crystals with enhanced chemical resistance and thermal stability.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and coupling reactions to incorporate the -CF2CO2Me group into complex molecular architectures.
• Fluorine Chemistry Research: A fundamental reagent in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	Methyl Bromodifluoroacetate
CAS No.	683-98-7
Molecular Formula	C3H3BrF2O2
Molecular Weight	188.96 g/mol
Synonyms	Bromodifluoroacetic Acid Methyl Ester; Methyl 2-Bromo-2,2-difluoroacetate; Difluorobromoacetic Acid Methyl Ester; Methyl α-Bromo-α,α-difluoroacetate; 2-Bromo-2,2-difluoroacetic Acid Methyl Ester; Bromodifluoroacetate de Méthyle; Methylbromodifluoroacetat
EINECS	211-689-6

Quality Control

Our Methyl Bromodifluoroacetate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and IR spectroscopy, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for manufacturing, ensuring reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.65 g/mL
Refractive Index (n20/D)	~1.39

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.