Description

[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Malonic Acid Diethyl Ester is a highly fluorinated malonic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethylated hydroxyethyl group, makes it a versatile precursor for introducing fluorinated motifs into target molecules, which is essential for modulating their physical, chemical, and biological properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorine atoms enhance bioavailability and environmental stability.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and specialty coatings with unique surface properties and chemical resistance.
• Organic Synthesis Building Block: A versatile reagent for constructing complex, fluorinated organic frameworks via reactions like Knoevenagel condensation, alkylation, and decarboxylation.
• Fluorine Chemistry Research: An important compound for academic and industrial research exploring new methodologies in fluorination and the effects of fluorine substitution.

Basic Information

Product Name	[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Malonic Acid Diethyl Ester
CAS No.	680-08-0
Molecular Formula	C₁₀H₁₂F₆O₅
Molecular Weight	326.19 g/mol
Synonyms	Diethyl 2-[1-Hydroxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]malonate; 1,1,1,3,3,3-Hexafluoro-2-(1,1-diethoxycarbonylmethyl)-2-propanol; 2-(1-Hydroxy-2,2,2-trifluoro-1-trifluoromethylethyl)malonic Acid Diethyl Ester; Hexafluoroisopropyl Malonate Derivative; TFIP-Malonic Ester; Ethyl 2-(1-Hydroxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl)malonate
EINECS	211-667-6

Quality Control

Our [2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Malonic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.