Description

[1-(Difluoromethyl)-2,2-Difluoro-1-Hydroxyethyl]Phosphonic Acid Diethyl Ester is a specialized organophosphorus compound featuring a unique difluoromethyl and difluoro-hydroxyethyl motif. This structure makes it a valuable fluorinated building block and intermediate for advanced synthesis in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients. The compound's utility lies in its ability to introduce fluorine-containing functional groups into complex molecules, enhancing their metabolic stability and binding properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting improved bioavailability and metabolic stability through fluorine incorporation.
• Agrochemical Research: Intermediate in the development of next-generation herbicides, insecticides, and fungicides where fluorinated groups can enhance activity and environmental profile.
• Material Science Precursor: Used in the research and development of fluorinated polymers, coatings, and specialty materials with unique surface properties.
• Organic Synthesis Reagent: Serves as a versatile reagent in academic and industrial laboratories for introducing phosphonate and fluorine groups into complex organic frameworks.
• Ligand and Catalyst Development: Potential precursor for creating novel fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	[1-(Difluoromethyl)-2,2-Difluoro-1-Hydroxyethyl]Phosphonic Acid Diethyl Ester
CAS No.	679-36-7
Molecular Formula	C7H12F4O4P
Molecular Weight	276.14 g/mol
Synonyms	Diethyl [1-(difluoromethyl)-2,2-difluoro-1-hydroxyethyl]phosphonate; (1-(Difluoromethyl)-2,2-difluoro-1-hydroxyethyl)phosphonic Acid Diethyl Ester; 1-Hydroxy-2,2-difluoro-1-(difluoromethyl)ethylphosphonic Acid Diethyl Ester; Phosphonic Acid, [1-(difluoromethyl)-2,2-difluoro-1-hydroxyethyl]-, Diethyl Ester; DFHP Diethyl Ester
EINECS	Contact for details

Quality Control

Our [1-(Difluoromethyl)-2,2-Difluoro-1-Hydroxyethyl]Phosphonic Acid Diethyl Ester is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed and stored in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.