Description

2-Hydroxy-2-(Trifluoromethyl)-3,3,3-trifluoropropionitrile is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a hydroxyl and a nitrile group flanked by trifluoromethyl moieties, makes it a critical intermediate for introducing high-value fluorinated segments into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, including protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with improved environmental profiles.
• Material Science: Serves as a precursor for fluorinated polymers, liquid crystals, and specialty coatings with unique surface properties.
• Organic Synthesis Building Block: Employed in nucleophilic addition reactions and cyclization processes to construct complex heterocycles.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation methodologies.

Basic Information

Product Name	2-Hydroxy-2-(Trifluoromethyl)-3,3,3-trifluoropropionitrile
CAS No.	677-77-0
Molecular Formula	C4HF6NO
Molecular Weight	193.05 g/mol
Synonyms	3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propanenitrile; 2-Hydroxy-2-(trifluoromethyl)-3,3,3-trifluoropropanenitrile; 2-(Trifluoromethyl)-3,3,3-trifluoro-2-hydroxypropionitrile; Hexafluoroacetone cyanohydrin; HFACN; Perfluoroacetone cyanohydrin
EINECS	211-646-5

Quality Control

Our 2-Hydroxy-2-(Trifluoromethyl)-3,3,3-trifluoropropionitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and organic solvents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.