Description

2,2-Difluorosuccinic Acid CAS NO 665-31-6 is a fluorinated derivative of succinic acid, characterized by its two fluorine atoms on the alpha carbon, which imparts unique reactivity and metabolic stability. This compound serves as a critical high-value building block in advanced organic synthesis, particularly for introducing fluorine motifs into target molecules. It is primarily utilized by pharmaceutical researchers and agrochemical developers seeking to enhance the biological activity and physicochemical properties of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where fluorine atoms can improve efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals with tailored surface properties.
• Biochemical Probe Synthesis: Useful for creating fluorinated analogs of natural metabolites to study enzymatic pathways and mechanisms.

Basic Information

Product Name	2,2-Difluorosuccinic Acid
CAS No.	665-31-6
Molecular Formula	C4H4F2O4
Molecular Weight	154.07 g/mol
Synonyms	2,2-Difluorobutanedioic Acid; Difluorobutanedioic Acid; 2,2-Difluorosuccinic Acid; Succinic Acid, 2,2-Difluoro-; 665-31-6; α,α-Difluorosuccinic Acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluorosuccinic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment. We adhere to relevant ISO guidelines and can support development under cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.