Description

2,2,3-Trifluoro-Succinic Acid is a high-purity fluorinated dicarboxylic acid building block, distinguished by its unique trifluoromethyl group. This compound is valued for its ability to introduce fluorine atoms and carboxylic acid functionality into target molecules, enhancing their metabolic stability, lipophilicity, and binding affinity. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other bioactive molecules requiring fluorinated motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Incorporated into polymers and coatings to impart unique surface properties, chemical resistance, and durability.
• Organic Synthesis Building Block: Employed in peptide mimetics and other complex organic molecules due to its bifunctional carboxylic acid groups.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	2,2,3-Trifluoro-Succinic Acid
CAS No.	664-66-4
Molecular Formula	C4H3F3O4
Molecular Weight	172.06 g/mol
Synonyms	2,2,3-Trifluorobutanedioic Acid; 3,3,4-Trifluorosuccinic Acid; 2,2,3-Trifluoro-1,4-butanedioic Acid; 2,2,3-Trifluorobutanedioic Acid; Trifluoromethylsuccinic Acid; 2,2,3-Trifluorosuccinic Acid; α,α,β-Trifluorobutanedioic Acid; NSC 37745
EINECS	Contact for details

Quality Control

Our 2,2,3-Trifluoro-Succinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, maintaining conditions at 2-8°C is recommended to ensure optimal stability of this moisture-sensitive compound.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.