Description

Propanoyl Chloride, 2-Chloro-3,3,3-Trifluoro-2-(Trifluoromethyl)- is a highly reactive and versatile fluorinated acid chloride intermediate. This compound is critical for introducing the hexafluoroisopropanol (HFIP) moiety into complex molecules, significantly altering their physical and chemical properties. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical and advanced materials sectors for synthesizing novel active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the hexafluoroisopropanol group to enhance metabolic stability, bioavailability, or membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms improves efficacy and environmental profile.
• Polymer & Material Science: Serves as a monomer or modifier in the production of specialty fluoropolymers, coatings, and resins with enhanced chemical resistance, thermal stability, and low surface energy.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic display technologies, contributing to improved performance and durability.
• Organic Synthesis Reagent: A valuable reagent in academic and industrial laboratories for acylations and the preparation of esters, amides, and ketones under mild conditions.

Basic Information

Product Name	Propanoyl Chloride, 2-Chloro-3,3,3-Trifluoro-2-(Trifluoromethyl)-
CAS No.	662-19-1
Molecular Formula	C4HClF6O
Molecular Weight	214.49 g/mol
Synonyms	2-Chloro-3,3,3-trifluoro-2-(trifluoromethyl)propanoyl Chloride; Hexafluoroisobutyryl Chloride; HFIB Chloride; 1,1,1,3,3,3-Hexafluoro-2-methyl-2-propanyl Chloroformate; Perfluoroisobutyryl Chloride; 2-Chloro-1,1,1,3,3,3-hexafluoro-2-methylpropan-1-one; α-Chlorohexafluoroisobutyryl Chloride
EINECS	211-553-5

Quality Control

Our Propanoyl Chloride, 2-Chloro-3,3,3-Trifluoro-2-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong bases, alcohols, and amines. Due to its highly volatile and moisture-sensitive nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) and handle in a fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.