Description

3'-Nitro-2,2,2-trifluoroacetophenone is a high-purity, specialized aromatic ketone building block distinguished by its nitro and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique structure imparts desirable properties to target compounds. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and fine chemical synthesis. Our supply ensures consistent quality and reliable availability for your most demanding synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those requiring fluorinated or nitro-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials.
• Organic Synthesis Reagent: Employed in various name reactions and as a starting material for preparing more complex heterocyclic compounds and ligands.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and process chemistry optimization in academic and industrial laboratories.

Basic Information

Product Name	3'-Nitro-2,2,2-trifluoroacetophenone
CAS No.	657-15-8
Molecular Formula	C8H4F3NO3
Molecular Weight	219.12 g/mol
Synonyms	1-(3-Nitrophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-3'-nitroacetophenone; 3-Nitro-α,α,α-trifluoroacetophenone; 3-Nitro-ω,ω,ω-trifluoroacetophenone; 3-Nitrophenyl trifluoromethyl ketone; 3-Nitro-α,α,α-trifluoroacetophenone; 3'-Nitro-α,α,α-trifluoroacetophenone; NSC 406906
EINECS	Contact for details

Quality Control

Every batch of 3'-Nitro-2,2,2-trifluoroacetophenone is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in opaque secondary packaging.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.