Description

3'-Bromo-2,2,2-trifluoroacetophenone is a versatile fluorinated aromatic ketone building block, distinguished by its bromine and trifluoromethyl substituents. This compound is highly valued for its role in facilitating nucleophilic aromatic substitution and serving as a precursor for complex heterocyclic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the bromine atom allows for further functionalization.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique optical or electronic properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex molecular architectures in medicinal chemistry and drug discovery programs.

Basic Information

Product Name	3'-Bromo-2,2,2-trifluoroacetophenone
CAS No.	655-26-5
Molecular Formula	C8H4BrF3O
Molecular Weight	253.02 g/mol
Synonyms	1-(3-Bromophenyl)-2,2,2-trifluoroethanone; 3-Bromo-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(3-bromophenyl)ethanone; 3'-Bromo-α,α,α-trifluoroacetophenone; m-Bromo-α,α,α-trifluoroacetophenone; 1-(3-Bromophenyl)-2,2,2-trifluoro-1-ethanone; 3-Bromophenyl trifluoromethyl ketone
EINECS	211-489-6

Quality Control

Our 3'-Bromo-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.