Description

2,2-Difluoro-2-Chloroacetophenone is a versatile fluorinated and chlorinated aromatic ketone building block, valued for its unique reactivity profile. This compound is essential for introducing difluoromethyl and carbonyl functionalities into target molecules, enabling the synthesis of complex chemical architectures. It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced material science sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the difluoromethyl group enhances bioavailability and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic semiconductors and liquid crystal compounds used in display technologies.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and condensation reactions to construct complex fluorinated heterocycles and fine chemicals.
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce fluorine into polymer backbones, altering physical properties like chemical resistance and thermal stability.
• Chemical Research (R&D): Utilized in academic and industrial laboratories for method development and exploring new reactions involving gem-difluoro compounds.

Basic Information

Product Name	2,2-Difluoro-2-Chloroacetophenone
CAS No.	653-13-4
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	α,α-Difluoro-α-chloroacetophenone; 2-Chloro-2,2-difluoroacetophenone; 2,2-Difluoro-2-chloro-1-phenylethanone; Phenacyl chloride, 2,2-difluoro-; 1-Phenylethanone, 2-chloro-2,2-difluoro-; Chlorodifluoroacetophenone; (Chlorodifluoroacetyl)benzene; NSC 406029
EINECS	211-483-5

Quality Control

Our 2,2-Difluoro-2-Chloroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring traceability and consistency for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.