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Isosorbide CAS NO 652-67-5
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CAS No.:652-67-5
Grade:Pharmacy Grade
Content:99.9%
Brand:Customizable
Packaging:Customizable
Description
Isosorbide is a versatile, bio-based diol derived from renewable starch sources, serving as a key building block for sustainable polymers and specialty chemicals. Its rigid V-shaped molecular structure imparts unique properties, making it a valuable, non-toxic alternative to petrochemical-derived intermediates. This product is essential for industries focused on green chemistry, including polymer manufacturing, pharmaceuticals, and personal care, where performance and environmental responsibility are paramount.
Application
- Polymer Industry: A crucial monomer for producing polycarbonates (PC), polyesters (PET, PTT), and polyurethanes (PUR), enhancing thermal stability, clarity, and rigidity.
- Pharmaceuticals: Used as an excipient and as a starting material for active pharmaceutical ingredients (APIs), notably in cardiovascular medications like isosorbide dinitrate and mononitrate.
- Personal Care & Cosmetics: Functions as a humectant and solvent in skin care, hair care, and cosmetic formulations, offering excellent moisture retention and low irritation.
- Chemical Synthesis: Acts as a chiral intermediate and platform chemical for synthesizing surfactants, plasticizers, and other fine chemicals.
- Green Solvents & Additives: Employed in the formulation of environmentally friendly solvents, coatings, and adhesive additives.
Basic Information
| Product Name | Isosorbide |
| CAS No. | 652-67-5 |
| Molecular Formula | C6H10O4 |
| Molecular Weight | 146.14 g/mol |
| Synonyms | 1,4:3,6-Dianhydro-D-glucitol; 1,4:3,6-Dianhydro-D-sorbitol; Isohexide; D-Isosorbide; (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol; Dianhydrosorbitol; NSC 407337; FEMA 4706 |
| EINECS | 211-463-1 |
Quality Control
Our Isosorbide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets the required specifications for purity, identity, and performance. Certificates of Analysis (COA) are provided with every shipment, detailing key parameters such as assay, optical rotation, and impurity profiles. We can supply grades suitable for industrial, cosmetic, and pharmaceutical applications, with compliance support for relevant frameworks.
Storage
Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent absorption of atmospheric moisture, which can affect product quality.
Specification
| Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification (IR) | Conforms |
| Assay (HPLC) | ≥ 98.0% |
| Optical Rotation | +40.0° to +44.0° (c=1 in H2O) |
| Melting Point | 60 - 65 °C |
| Water Content (KF) | ≤ 1.0% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals (as Pb) | ≤ 10 ppm |
Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.
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Trusted Manufacturer
With our own production facilities, we ensure consistent quality, reliable supply, and full traceability.
Rigorous Quality Assurance
Each batch undergoes strict QC, accompanied by COA, MSDS, and full compliance with international standards.
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Our in-house lab drives process innovation, new product development, and tailored synthesis solutions.






