Description

2',3',4',5',6'-Pentafluoroacetophenone is a highly fluorinated aromatic ketone, serving as a critical building block in advanced organic synthesis. Its unique perfluorinated aromatic ring structure makes it an invaluable intermediate for introducing fluorine atoms into complex molecules, which is essential for modifying their physical, chemical, and biological properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), where fluorine substitution can enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used to develop novel fluorinated herbicides, fungicides, and insecticides, leveraging fluorine's ability to increase lipophilicity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving thermal stability and optical properties.
• Polymer & Specialty Chemical Modifier: Incorporated into polymers and coatings to impart oil/water repellency, chemical resistance, and low surface energy characteristics.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions, nucleophilic aromatic substitution, and as a directing group in metal-catalyzed transformations in research laboratories.

Basic Information

Product Name	2',3',4',5',6'-Pentafluoroacetophenone
CAS No.	652-29-9
Molecular Formula	C8H3F5O
Molecular Weight	210.10 g/mol
Synonyms	Pentafluoroacetophenone; 2,3,4,5,6-Pentafluoroacetophenone; 1-(Pentafluorophenyl)ethanone; Pentafluorophenyl methyl ketone; α,α,α,2,3,4,5,6-Octafluoroacetophenone (incorrect but sometimes used); Acetophenone, pentafluoro-; PFP-COCH3; EINECS 211-480-8
EINECS	211-480-8

Quality Control

Every batch of 2',3',4',5',6'-Pentafluoroacetophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via GC, HPLC, NMR, and IR is supplied with each shipment. Our quality protocols are designed to support cGMP and ISO standards for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.