Description

Octafluoroacetophenone CAS NO 652-22-2 is a highly fluorinated aromatic ketone characterized by its unique perfluorinated phenyl ring. This compound is a critical fluorinated building block and intermediate in advanced organic synthesis, valued for its ability to impart significant lipophilicity, metabolic stability, and electron-withdrawing properties to target molecules. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for applications ranging from drug discovery to the development of novel functional polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), where fluorine substitution enhances bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced, high-performance herbicides and pesticides, leveraging fluorine's ability to increase lipophilicity and environmental persistence.
• Liquid Crystal Materials: Serves as a core component in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its strong dipole moment and stability.
• Polymer & Material Science: Acts as a monomer or modifier in creating specialty fluoropolymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Electronics: Employed in the development of electron-transport materials and semiconductors for OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile reagent for introducing perfluorophenyl groups in medicinal chemistry and material science research programs.

Basic Information

Product Name	Octafluoroacetophenone
CAS No.	652-22-2
Molecular Formula	C8H2F8O
Molecular Weight	266.09 g/mol
Synonyms	2,3,4,5,6-Pentafluoro-α,α,α-trifluoroacetophenone; Perfluoroacetophenone; 1-(Perfluorophenyl)ethan-1-one; Pentafluorophenyl trifluoromethyl ketone; α,α,α,2,3,4,5,6-Octafluoroacetophenone; Octafluoroacetophenone; OFAP; EINECS 211-483-1
EINECS	211-483-1

Quality Control

Our Octafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for sensitive pharmaceutical and electronic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to potential sensitivity to moisture, containers should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Specific Impurity A	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.