Description

2-(Trifluoromethyl)Thiophene is a high-purity fluorinated heterocyclic building block, also known as 2-(Trifluoroacetyl)Thiophene CAS NO 651-70-7. This compound is valued for its unique reactivity, where the electron-withdrawing trifluoromethyl group adjacent to the thiophene ring enables precise synthesis of complex molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated thiophene motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Organic Electronics: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand & Catalyst Development: Employed in organometallic chemistry to create specialized ligands for catalysis, leveraging the thiophene sulfur for metal coordination.
• Material Science Research: A building block for novel fluorinated polymers and coatings with specific thermal, chemical, or surface properties.
• Chemical Research & Development: A versatile reagent for method development and exploring new fluorination reactions and heterocyclic chemistry.

Basic Information

Product Name	2-(Trifluoromethyl)Thiophene
CAS No.	651-70-7
Molecular Formula	C5H3F3S
Molecular Weight	152.14 g/mol
Synonyms	2-(Trifluoroacetyl)Thiophene; α,α,α-Trifluoro-2-thienyl ketone; 2-Thienyl trifluoromethyl ketone; 2-Trifluoroacetylthiophene; 1-(Thiophen-2-yl)-2,2,2-trifluoroethanone; 2-Thienyltrifluoromethylketone; Thiophene-2-trifluoromethyl ketone; 2-(Trifluoromethyl)thiophene
EINECS	211-475-5

Quality Control

Every batch of 2-(Trifluoromethyl)Thiophene is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by GC/HPLC), identity (IR, NMR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat, sparks, and open flame. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.