Description

4-(Trifluoromethylsulfonyl)Benzaldehyde is a high-value, multi-functional aromatic aldehyde building block distinguished by its trifluoromethanesulfonyl (triflyl) substituent. This compound is critical for introducing both the aldehyde and the strongly electron-withdrawing triflyl group into target molecules, enabling advanced synthesis in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring the trifluoromethanesulfonyl pharmacophore.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides where the triflyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a building block for creating novel ligands and organocatalysts in asymmetric synthesis and transition metal catalysis.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic electronic materials due to its electron-accepting properties.
• Cross-Coupling Reactions: The aldehyde group allows for further functionalization, while the aryl moiety can participate in Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry Research: An essential reagent for studying the effects of super-strong electron-withdrawing groups on reaction kinetics and molecular properties.

Basic Information

Product Name	4-(Trifluoromethylsulfonyl)Benzaldehyde
CAS No.	650-89-5
Molecular Formula	C8H5F3O3S
Molecular Weight	238.18 g/mol
Synonyms	4-(Trifluoromethanesulfonyl)benzaldehyde; alpha,alpha,α-Trifluoro-4-formylbenzenesulfonamide; p-(Trifluoromethylsulfonyl)benzaldehyde; 4-Formylphenyl trifluoromethyl sulfone; Benzaldehyde, 4-[(trifluoromethyl)sulfonyl]-; 4-(Triflyl)benzaldehyde; p-Triflylbenzaldehyde; 4-(Trifluoromethanesulfonyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethylsulfonyl)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.