Description

Ethyl 3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyrate is a versatile fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl moiety, makes it a critical intermediate for introducing fluorine atoms into target molecules, thereby enhancing their metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral, anti-inflammatory, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display materials, leveraging fluorine's properties to improve performance.
• Advanced Polymer Modifiers: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and stability.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex molecules via reactions at the hydroxyl or ester functional groups.

Basic Information

Product Name	Ethyl 3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyrate
CAS No.	649-67-2
Molecular Formula	C7H11F3O3
Molecular Weight	200.16 g/mol
Synonyms	3-Hydroxy-3-methyl-4,4,4-trifluorobutanoic acid ethyl ester; Ethyl 3-hydroxy-3-methyl-4,4,4-trifluorobutanoate; 4,4,4-Trifluoro-3-hydroxy-3-methylbutyric acid ethyl ester; 649-67-2; Butanoic acid, 3-hydroxy-3-methyl-4,4,4-trifluoro-, ethyl ester; Ethyl 4,4,4-trifluoro-3-hydroxy-3-methylbutyrate
EINECS	211-475-5

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards and precise customer requirements. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) is provided with each batch, detailing all relevant specifications. Our quality management system supports the production of material suitable for research and commercial scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index	1.380 - 1.390
Density	1.25 - 1.35 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.