Description

1-Chloro-3-Fluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine substituents in the meta position, makes it a critical intermediate for introducing specific reactivity and electronic properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key starting material in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Polymer & Resin Modification: Employed to introduce halogen functionality into polymers and specialty resins, altering their physical and chemical resistance properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	1-Chloro-3-Fluorobenzene
CAS No.	625-98-9
Molecular Formula	C6H4ClF
Molecular Weight	130.55 g/mol
Synonyms	3-Chlorofluorobenzene; m-Chlorofluorobenzene; 3-Fluorochlorobenzene; m-Fluorochlorobenzene; 1-Fluoro-3-chlorobenzene; Benzene, 1-chloro-3-fluoro-; F3ClB (abbreviation)
EINECS	210-921-0

Quality Control

Our 1-Chloro-3-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong acids/organic solvents and fluorides/strong alkalis. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.5%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	1.250 - 1.270 g/mL
Boiling Point	~ 124-126 °C
Refractive Index (n20D)	1.495 - 1.500

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.