Description

L-Phenylephrine is a potent and selective α-1 adrenergic receptor agonist, widely recognized for its vasoconstrictive properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of pharmaceutical formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of nasal decongestants, ophthalmic solutions, and treatments for hypotension.

Application

• Pharmaceutical API: Core ingredient in over-the-counter and prescription nasal decongestant sprays and drops.
• Ophthalmic Solutions: Used in eye drops to induce mydriasis (pupil dilation) for diagnostic procedures and to reduce redness.
• Vasopressor Agent: Employed in clinical settings to manage hypotension, particularly during spinal anesthesia.
• Research & Development: A key reference standard and tool compound in pharmacological studies of adrenergic receptors.
• Veterinary Medicine: Applied in formulations for similar vasoconstrictive purposes in animal health.
• Combination Drugs: Formulated with other APIs in multi-symptom relief cold and allergy medications.

Basic Information

Product Name	L-Phenylephrine
CAS No.	614-03-9
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	(R)-(-)-Phenylephrine; (-)-L-Phenylephrine; (R)-(-)-m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol; L-(-)-Phenylephrine; (-)-m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol; Metasympatol; Neo-Synephrine (as the hydrochloride salt); (1R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethanol
EINECS	210-359-6

Quality Control

Our L-Phenylephrine is manufactured under strict quality management systems. It is tested to meet high-purity standards suitable for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for identity, purity, assay, and related substances. We ensure traceability, consistency, and regulatory compliance for all our shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Specific Rotation	-50° to -55° (c=2 in water)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.