Description

Tramazoline Hydrochloride is a potent, synthetic α-adrenergic receptor agonist. This compound is of significant commercial interest due to its primary use as a decongestant in pharmaceutical formulations. It is a critical active pharmaceutical ingredient (API) for manufacturers developing nasal sprays and ophthalmic solutions targeting congestion and redness. The product is supplied under the identifier CAS NO 3715-90-0 to ensure precise sourcing and regulatory compliance.

Application

• Pharmaceutical API: Primary use as the active ingredient in nasal decongestant sprays.
• Ophthalmic Solutions: Key component in eye drops formulated to relieve redness and irritation.
• Veterinary Medicine: Used in topical decongestant preparations for animals.
• Research & Development: Serves as a reference standard and building block in pharmacological studies of adrenergic agents.
• Formulation Development: Utilized in the development of combination drug products for cold and allergy relief.
• Contract Manufacturing: Supplied to CMOs for the production of finished dosage forms under GMP guidelines.

Basic Information

Product Name	Tramazoline Hydrochloride
CAS No.	3715-90-0
Molecular Formula	C13H17N3·HCl
Molecular Weight	251.76 g/mol
Synonyms	Tramazoline HCl; 2-[(5,6,7,8-Tetrahydronaphthalen-1-yl)amino]-4,5-dihydro-1H-imidazole Hydrochloride; Tramazolin Hydrochloride; Tramazoline Monohydrochloride; Y-27152; Decongestant Y-27152; 1H-Imidazole, 4,5-dihydro-2-[(5,6,7,8-tetrahydro-1-naphthalenyl)amino]-, monohydrochloride
EINECS	223-058-8

Quality Control

Our Tramazoline Hydrochloride is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, aligning with ICH Q7 guidelines for Active Pharmaceutical Ingredients (APIs). A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results from tests including assay, related substances, residual solvents, and microbiological examination.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature between 15°C and 25°C (59°F and 77°F). The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Microbial Enumeration	Complies with Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.