Description

Ethyl 2-Chloroacetoacetate is a versatile chlorinated β-ketoester building block essential for synthesizing complex heterocyclic and pharmaceutical intermediates. Its high reactivity, particularly at the α-position to the carbonyl and ester groups, makes it a critical reagent for introducing functionalized acetyl units. This compound is primarily sought by R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing active molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various heterocyclic compounds, including pyrazoles, isoxazoles, and pyrimidines, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the manufacturing of herbicides, fungicides, and insecticides, where the chloroacetyl moiety is incorporated for bioactivity.
• Fine Chemical Production: Serves as a building block for dyes, pigments, and specialty chemicals requiring functionalized acetoacetate derivatives.
• Chemical Research & Development: Employed in organic synthesis for Claisen condensations, alkylation reactions, and as a starting material for complex molecular scaffolds.

Basic Information

Product Name	Ethyl 2-Chloroacetoacetate
CAS No.	609-15-4
Molecular Formula	C6H9ClO3
Molecular Weight	164.59 g/mol
Synonyms	2-Chloroacetoacetic Acid Ethyl Ester; Ethyl 2-Chloro-3-oxobutanoate; Ethyl α-Chloroacetoacetate; Acetoacetic Acid, 2-Chloro-, Ethyl Ester; 3-Oxobutanolic Acid, 2-Chloro-, Ethyl Ester; Ethyl Chloroacetoacetate; 609-15-4; NSC 401801
EINECS	210-184-6

Quality Control

Our Ethyl 2-Chloroacetoacetate is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing including GC, HPLC, and NMR to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); ensure containers are kept tightly sealed to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.448 - 1.452
Density (20°C)	1.218 - 1.228 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.