Description

5-Trifluoromethylthiophene-2-Boronic Acid Pinacol Ester is a high-purity organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in cross-coupling reactions, enabling the efficient construction of complex molecules for advanced material and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel compounds with tailored properties.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to introduce the 5-trifluoromethylthiophene moiety into target molecules.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those requiring the bioisosteric and metabolically stable trifluoromethylthiophene group.
• Agrochemical Development: Employed in creating novel herbicides, fungicides, and insecticides where the unique electronic properties of the trifluoromethylthiophene unit enhance biological activity.
• Material Science & Organic Electronics: Serves as a precursor for synthesizing advanced organic semiconductors, conductive polymers, and non-linear optical materials.
• Ligand & Catalyst Design: Useful in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Facilitates the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.

Basic Information

Item	Detail
Product Name	5-Trifluoromethylthiophene-2-Boronic Acid Pinacol Ester
CAS No.	596819-13-5
Molecular Formula	C11H14BF3O2S
Molecular Weight	278.10 g/mol
Synonyms	2-(5-(Trifluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-(Trifluoromethyl)thiophene-2-boronic acid pinacol ester; 2-(5-Trifluoromethyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Trifluoromethyl-2-thiopheneboronic Acid Pinacol Ester; 5-Trifluoromethylthiophene-2-Boronic Acid Neopentyl Glycol Ester (common alternative); 5-CF3-Thiophene-2-BPin
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethylthiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.