Description

6H-Cyclopenta[B]Furan-6-One, Hexahydro-3A,6A-Dihydroxy-, (3Ar,6Ar)-Rel- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, enabling precise control over the final product's structure and efficacy. It is essential for research and development chemists and process engineers in the pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for API development and scale-up.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or metabolic disorder targets.
• Asymmetric Synthesis: Utilized in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Process Chemistry Development: Used for route scouting and process optimization during the scale-up of drug candidates from laboratory to pilot plant and commercial manufacturing.
• Fine Chemical Production: Acts as a precursor for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemical configurations.

Basic Information

Product Name	6H-Cyclopenta[B]Furan-6-One, Hexahydro-3A,6A-Dihydroxy-, (3Ar,6Ar)-Rel- (9Ci)
CAS No.	587875-10-3
Molecular Formula	C7H10O4
Molecular Weight	158.15 g/mol
Synonyms	rel-(3aR,6aR)-Hexahydro-3a,6a-dihydroxycyclopenta[b]furan-6-one; (3aR,6aR)-Hexahydro-3a,6a-dihydroxy-6H-cyclopenta[b]furan-6-one; 6H-Cyclopenta[b]furan-6-one, hexahydro-3a,6a-dihydroxy-, (3aR,6aR)-rel-; Dihydroxycyclopentafuranone; Chiral Dihydroxy Lactone Intermediate; 587875-10-3
EINECS	Contact for details

Quality Control

Our production of 6H-Cyclopenta[B]Furan-6-One, Hexahydro-3A,6A-Dihydroxy-, (3Ar,6Ar)-Rel- (9Ci) adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.