Description

Losmapimod (GW856553X) is a potent and selective small-molecule inhibitor of p38 mitogen-activated protein kinase (MAPK) alpha and beta isoforms. This compound is a critical research tool for investigating inflammatory signaling pathways and their role in various disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery for inflammatory and autoimmune conditions.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) in preclinical studies for inflammatory diseases.
• Mechanistic Biology Studies: Used to elucidate the role of p38 MAPK signaling in cellular processes like cytokine production, apoptosis, and stress response.
• Drug Discovery Screening: Serves as a positive control or benchmark compound in high-throughput screening assays targeting kinase inhibition.
• Inflammatory Disease Modeling: Applied in in vitro and in vivo models to study conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and cardiovascular inflammation.
• Biochemical Assay Development: Utilized in developing and validating enzymatic assays for p38 MAPK activity and inhibitor potency testing.

Basic Information

Product Name	Losmapimod (GW856553X)
CAS No.	585543-15-3
Molecular Formula	C₂₃H₂₅FN₄O₃
Molecular Weight	424.47 g/mol
Synonyms	GW856553X; GW-856553; Losmapimod; 6-(5-((cyclopropylamino)methyl)-3-fluoropyridin-2-yl)-5-methyl-4,5-dihydro-1H-benzo[d][1,3]oxazin-2-one; p38 MAP kinase inhibitor Losmapimod; GSK-AHAB
EINECS	Contact for details

Quality Control

Our Losmapimod is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.