Description

4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)chlorobenzene is a high-purity organoboron compound, specifically a pinacol boronate ester derivative, valued for its stability and reactivity in advanced chemical synthesis. This compound serves as a crucial synthetic intermediate, enabling precise carbon-carbon bond formation through cross-coupling reactions. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific biphenyl or substituted phenyl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where controlled aryl-aryl coupling is essential.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and labeling strategies in probe and tracer molecule development.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.

Basic Information

Product Name	4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)chlorobenzene
CAS No.	585524-80-7
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	4-Chlorophenylboronic acid pinacol ester; (4-Chlorophenyl)boronic acid pinacol ester; 4-Chlorophenyl-5,5-dimethyl-1,3,2-dioxaborinane; 1-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (common pinacol boronate naming); 4-Chlorobenzeneboronic acid pinacol cyclic ester; 2-(4-Chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; p-Chlorophenylboronic acid pinacol ester; 4-ClC6H4Bpin
EINECS	Contact for details

Quality Control

Our 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)chlorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC-MS, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.