Description

(E)-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)But-3-En-2-Ol is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group. This compound is a critical building block in modern synthetic organic chemistry, enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex target molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the introduction of the (E)-2-methylbut-3-en-2-ol fragment into complex organic frameworks.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: A precursor for functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Useful for the synthesis of tagged molecules and probes for biological target identification.

Basic Information

Product Name	(E)-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)But-3-En-2-Ol
CAS No.	581802-26-8
Molecular Formula	C11H21BO3
Molecular Weight	212.09 g/mol
Synonyms	(E)-2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-ol; 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-buten-1-ol (E)-; (E)-2-Methyl-2-buten-1-ol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; trans-2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-ol; Pinacol (E)-2-methyl-4-(hydroxymethyl)but-2-en-1-ylboronate; (E)-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylbut-3-en-2-ol
EINECS	Contact for details

Quality Control

Our (E)-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)But-3-En-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and handle it in a moisture-controlled environment (e.g., glovebox) for long-term stability. Recommended storage temperature: 2-8°C for prolonged storage; short-term at 15-25°C is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (GC/HPLC)	≥ 95.0% (E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.