Description

D-Proline, 1-(Aminocarbonyl)-, Methyl Ester (9Ci) is a high-purity, non-natural amino acid derivative with a defined stereochemistry. This compound matters as a crucial chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise spatial orientation. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in peptide mimetics, active pharmaceutical ingredient (API) development, and asymmetric catalysis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly peptidomimetics and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs, modifying the biological activity and stability of peptide sequences.
• Asymmetric Synthesis: Serves as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Biochemical Research: Employed as a standard or reagent in studies of enzyme kinetics, protein structure, and metabolic pathways involving proline.
• Agrochemical Development: Utilized in the synthesis of advanced, chiral active ingredients for crop protection products.
• Material Science: A potential monomer for creating specialty polymers with unique structural properties.

Basic Information

Product Name	D-Proline, 1-(Aminocarbonyl)-, Methyl Ester (9Ci)
CAS No.	578741-04-5
Molecular Formula	C7H12N2O3
Molecular Weight	172.18 g/mol
Synonyms	Methyl (2R)-1-carbamoylpyrrolidine-2-carboxylate; D-1-Carbamoylproline Methyl Ester; (R)-1-Carbamoylpyrrolidine-2-carboxylic Acid Methyl Ester; Methyl N-Carbamoyl-D-prolinate; (R)-Pyrrolidine-2-carboxylic Acid, 1-Carbamoyl-, Methyl Ester; D-Proline, N-carboxy-, Methyl Ester, Amide; 578741-04-5; (R)-1-Carbamoylpyrrolidine-2-carboxylate Methyl Ester
EINECS	Contact for details

Quality Control

Our D-Proline, 1-(Aminocarbonyl)-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.