Description

(R)-tert-Butyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)benzyl)piperidine-3-carboxylate is a high-purity, chiral boronic ester building block essential for modern synthetic chemistry. Its primary value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is critically needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting neurological and metabolic disorders.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester reagent for forming carbon-carbon bonds with high stereochemical fidelity, crucial for creating complex molecular architectures.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds where the (R)-configuration of the piperidine ring is required for biological activity.
• Agrochemical Research: Employed in the discovery and development of novel, chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric transformations.
• Material Science Exploration: Investigated as a building block for advanced organic materials, such as chiral polymers or liquid crystals.

Basic Information

Item	Details
Product Name	(R)-tert-Butyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)benzyl)piperidine-3-carboxylate
CAS No.	578729-05-2
Molecular Formula	C24H38BNO4
Molecular Weight	415.38 g/mol
Synonyms	(R)-tert-Butyl 1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl)piperidine-3-carboxylate; (R)-3-((tert-Butoxy)carbonyl)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine; (R)-1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine-3-carboxylic acid tert-butyl ester; (R)-Pinacolyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine-3-carboxylate (tert-butyl ester); Boron, [1-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-3-piperidinyl]carboxylic acid 1,1-dimethylethyl ester, (3R)-; 578729-05-2; (R)-tert-Butyl 1-(4-borono benzyl)piperidine-3-carboxylate pinacol ester
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)benzyl)piperidine-3-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR (1H, 11B, 13C), and mass spectrometry, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Enantiomeric Excess (Chiral HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.