Description

3-(Benzyloxy)-4-(Difluoromethoxy)Benzaldehyde is a specialized aromatic aldehyde building block featuring both benzyloxy and difluoromethoxy substituents. This compound is valued for its unique molecular structure, which serves as a critical intermediate in the synthesis of complex, high-value molecules, particularly in advanced pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists working on novel active ingredients, where the introduction of fluorine atoms and protected phenolic groups is required to modulate biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) targets and kinase inhibitors where the difluoromethoxy group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the benzaldehyde core for further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and advanced polymers, where its aromatic and fluorine-containing structure can influence electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring this specific fluorinated benzaldehyde derivative.

Basic Information

Product Name	3-(Benzyloxy)-4-(Difluoromethoxy)Benzaldehyde
CAS No.	577968-58-2
Molecular Formula	C15H12F2O3
Molecular Weight	278.25 g/mol
Synonyms	4-(Difluoromethoxy)-3-(phenylmethoxy)benzaldehyde; Benzaldehyde, 3-(benzyloxy)-4-(difluoromethoxy)-; 3-Benzyloxy-4-difluoromethoxybenzaldehyde; 4-(Difluoromethoxy)-3-benzyloxybenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-(Benzyloxy)-4-(Difluoromethoxy)Benzaldehyde is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to support regulatory filings in pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); it is recommended to handle and store under an inert atmosphere such as nitrogen or argon for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.