Description

Cyclopropanecarboxylic Acid, 2-Borono-1-Methyl-, 1-Methyl Ester, (1S,2R)- is a high-purity, stereochemically defined boronic ester building block. This compound matters for its critical role in modern synthetic chemistry, particularly in facilitating Suzuki-Miyaura cross-coupling reactions to construct complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of advanced intermediates and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel therapeutic agents, including protease inhibitors and other small molecule drugs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile organoboron reagent for the formation of carbon-carbon bonds in complex molecule assembly.
• Agrochemical Research: Used in the development of new, more effective pesticides and herbicides with specific stereochemical requirements.
• Material Science: Employed in the research and development of advanced organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological pathways and target engagement.
• Catalyst Ligand Synthesis: Acts as a precursor for the development of novel chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Borono-1-Methyl-, 1-Methyl Ester, (1S,2R)-
CAS No.	570431-58-2
Molecular Formula	C7H13BO4
Molecular Weight	171.99 g/mol
Synonyms	(1S,2R)-2-Borono-1-methylcyclopropanecarboxylic acid 1-methyl ester; (1S,2R)-1-Methyl 2-borono-1-methylcyclopropanecarboxylate; (1S,2R)-Methyl 2-borono-1-methylcyclopropanecarboxylate; (1S,2R)-Methyl 1-methyl-2-boronocyclopropanecarboxylate; trans-(1S,2R)-Methyl 2-borono-1-methylcyclopropanecarboxylate; Boronic acid, B-[(1S,2R)-2-(methoxycarbonyl)-1-methylcyclopropyl]-; A chiral cyclopropylboronic ester.
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Borono-1-Methyl-, 1-Methyl Ester, (1S,2R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full specification data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.