Description

2-(Benzo[B]Thiophen-2-Yl)-5,5-Dimethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a benzo[b]thiophene-substituted cyclic boronic ester. This compound is critical for enabling advanced cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to modern pharmaceutical and materials science research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing the benzo[b]thiophene scaffold.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science & OLED Development: Serves as a building block for creating organic semiconductors, light-emitting materials, and charge-transport layers in electronic devices.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a stable, air-handleable boronic ester partner for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Ligand & Catalyst Design: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological processes and target engagement.

Basic Information

Product Name	2-(Benzo[B]Thiophen-2-Yl)-5,5-Dimethyl-1,3,2-Dioxaborolane
CAS No.	568572-21-4
Molecular Formula	C₁₃H₁₅BO₂S
Molecular Weight	246.13 g/mol
Synonyms	2-(1-Benzothiophen-2-yl)-5,5-dimethyl-1,3,2-dioxaborolane; 2-(Benzo[b]thiophen-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; Benzo[b]thiophene-2-boronic acid, 5,5-dimethyl-1,3,2-dioxaborolane ester; 2-(2-Benzo[b]thienyl)-5,5-dimethyl-1,3,2-dioxaborolane; 2-(Benzothiophen-2-yl)-5,5-dimethyl-1,3,2-dioxaborolane; BT-2-BPin; Contact for further synonyms.
EINECS	Contact for details

Quality Control

Our 2-(Benzo[B]Thiophen-2-Yl)-5,5-Dimethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) with full analytical data are provided to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle and store the product under an inert atmosphere (argon or nitrogen) for long-term stability and to maintain optimal reactivity. Recommended storage temperature: 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.