Description

2-(4-Methoxy-3,5-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl or heteroaryl halides and this boronic ester, widely used in pharmaceutical intermediate synthesis.
• Pharmaceutical Intermediate Manufacturing: Serves as a versatile building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-moiety incorporation.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, ligands for catalysts, and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Useful for creating tagged molecules and bioconjugates for research and diagnostic applications.
• Scale-up Process Chemistry: Suitable for transitioning from laboratory-scale discovery to pilot plant and commercial manufacturing due to its stability and reactivity profile.

Basic Information

Product Name	2-(4-Methoxy-3,5-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	568572-19-0
Molecular Formula	C₁₅H₂₃BO₃
Molecular Weight	262.15 g/mol
Synonyms	4-Methoxy-3,5-dimethylbenzeneboronic acid pinacol ester; (4-Methoxy-3,5-dimethylphenyl)boronic acid pinacol ester; 2-(4-Methoxy-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (4-Methoxy-3,5-dimethylphenyl)boronate; 4-Methoxy-3,5-dimethylphenyl-Bpin; Boronic acid, B-(4-methoxy-3,5-dimethylphenyl)-, 1,1,1,1-tetramethyl-2,2-diethyl ester; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our 2-(4-Methoxy-3,5-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is produced and tested under strict quality management systems to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. Our quality commitment supports applications requiring material traceability and compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged operations or when storing opened containers to maintain purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.