Description

Boc-8-Amino-3,6-Dioxaoctanoic Acid Dcha is a high-purity, protected amino acid derivative featuring a polyethylene glycol (PEG) spacer, which is essential for modifying the solubility and pharmacokinetic properties of bioactive molecules. This compound is a critical building block in the synthesis of peptide-drug conjugates (PDCs), antibody-drug conjugates (ADCs), and other advanced therapeutic modalities. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of targeted cancer therapies and novel bioconjugates.

Application

• Linker for Antibody-Drug Conjugates (ADCs): Serves as a key component in constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies for targeted cancer treatment.
• Peptide-Drug Conjugate (PDC) Synthesis: Used as a functionalized spacer to attach therapeutic agents to targeting peptides, enhancing drug delivery specificity and efficacy.
• PEGylation Reagent: The built-in 8-amino-3,6-dioxaoctanoic acid (PEG2) unit acts as a solubility-enhancing linker for modifying proteins, peptides, and small molecules.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected, side-chain modified amino acid for introducing PEG-like spacers into custom peptide sequences during Fmoc/t-Bu chemistry.
• Prodrug Development: Facilitates the creation of prodrugs where the Boc-protected amine and carboxylic acid groups allow for controlled release of active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Provides a handle for attaching fluorescent dyes, biotin, or other reporter molecules to biomolecules for diagnostic and research applications.

Basic Information

Product Name	Boc-8-Amino-3,6-Dioxaoctanoic Acid Dcha
CAS No.	560088-79-1
Molecular Formula	C21H40N2O6
Molecular Weight	416.56 g/mol
Synonyms	8-[(tert-Butoxycarbonyl)amino]-3,6-dioxaoctanoic Acid Dicyclohexylamine Salt; Boc-NH-PEG2-COOH DCHA Salt; 2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic Acid Dicyclohexylamine Salt; Boc-8-Amino-3,6-dioxaoctanoic Acid DCHA Salt; Boc-AEEA-OH DCHA Salt; Nα-(tert-Butoxycarbonyl)-8-amino-3,6-dioxaoctanoic Acid Dicyclohexylammonium Salt; Fmoc-PEG2-COOH Precursor DCHA Salt
EINECS	Contact for details

Quality Control

Our Boc-8-Amino-3,6-Dioxaoctanoic Acid Dcha is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D and GMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.