Description

1-Methyl-1H-Imidazole-2-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry, particularly in cross-coupling reactions. This compound serves as a critical building block for constructing complex heterocyclic scaffolds found in pharmaceuticals and advanced materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, enabling the synthesis of novel imidazole-containing compounds.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Serves as a building block for creating new fungicides, herbicides, and plant growth regulators with imidazole cores.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and bioconjugates to study biological processes.
• Process Chemistry & Scale-up: The pinacol ester protection enhances stability, making it suitable for multi-step synthesis and larger-scale manufacturing processes.

Basic Information

Product Name	1-Methyl-1H-Imidazole-2-Boronic Acid Pinacol Ester
CAS No.	553651-31-3
Molecular Formula	C₁₀H₁₇BN₂O₂
Molecular Weight	208.07 g/mol
Synonyms	1-Methyl-1H-imidazole-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-imidazole; 1-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole; 1-Methyl-1H-imidazol-2-ylboronic acid pinacol ester; 1-Methylimidazole-2-boronic acid pinacol ester; N-Methyl-2-imidazoleboronic acid pinacol ester; 2-Borono-1-methylimidazole pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Imidazole-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and HPLC, to ensure high purity and consistency suitable for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.