Description

4-Methoxy-3-(trifluoromethyl)phenacyl bromide is a specialized brominated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the phenacyl bromide moiety combined with the electron-donating methoxy and electron-withdrawing trifluoromethyl substituents, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile building block for creating sophisticated ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized monomers and polymers with tailored optical or electronic properties.
• Chemical Biology Probes: Utilized as a reactive handle for the site-specific modification of proteins and other biomolecules in probe development.
• Cross-Coupling Reactions: Acts as an effective electrophile in various palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	4-Methoxy-3-(Trifluoromethyl)Phenacyl Bromide
CAS No.	541550-00-9
Molecular Formula	C10H8BrF3O2
Molecular Weight	297.07 g/mol
Synonyms	2-Bromo-1-[4-methoxy-3-(trifluoromethyl)phenyl]ethan-1-one; 1-(4-Methoxy-3-(trifluoromethyl)phenyl)-2-bromoethanone; 4-Methoxy-3-(trifluoromethyl)phenacyl bromide; α-Bromo-4-methoxy-3-(trifluoromethyl)acetophenone; 2-Bromo-4'-methoxy-3'-(trifluoromethyl)acetophenone; 541550-00-9; Bromo(4-methoxy-3-trifluoromethylphenyl)methanone
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3-(trifluoromethyl)phenacyl bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.